Interleukin-21 Enhances NK Cell Activation
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چکیده
منابع مشابه
IL-21 enhances antitumor responses without stimulating proliferation of malignant T cells of patients with Sézary syndrome.
IL-21, a common gamma-chain cytokine secreted by activated CD4+ T cells, influences both humoral and cell-mediated immune responses through the regulation of T, B, dendritic, and natural killer (NK) cells. Sézary syndrome is an advanced form of cutaneous T-cell lymphoma, a clonally derived malignancy of CD4+ T cells that is characterized by profound defects in host cellular immune function. As ...
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Immune system protects body from invading pathogens and other microbes. The immune system consists of white blood cells, leukocytes, which form a complex network along with soluble mediators, cytokines, by which the cells communicate with each other. In addition to secreted soluble mediators, the cells have also direct interactions with each other via their cell surface receptors. The immune sy...
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Interleukin (IL)-21 induces proliferation of activated T and natural killer (NK) cells and enhances the lytic function of NK cells. IL-23, a heterodimer composed of p19 and p40 molecule, can also enhance T cell proliferation and interferon-gamma production from activated T cells; however, its effects on NK cells are currently unknown. We therefore examined whether human tumors expressing IL-21 ...
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Background: Perforin is known to be important in cytolytic activity mediated by natural killer (NK) cells. Objective: To study the relationship between the efficiency of NK and lymphokine-activated killer (LAK) cells activity, and the expression of perforin and HLA class I molecules. Methods: LAK cells were generated by in vitro culturing of human peripheral blood lymphocytes (PBLs) in the ...
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Adoptive transfer of NK cells has been widely applied clinically for cancer immunotherapy. However, the difficulties to obtain a large number of activated NK cells impede the successful application of such therapy. In the present study, we implemented a novel method involving the use of immobilized human 4-1BBL and interleukin-21 to amplify NK cells from the peripheral blood mononuclear cells (...
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